Analysis of Randomized Controlled Trials (RCTs)

Expert RCT Analysis for Evidence-Based Research

At Clievi.com, we provide comprehensive analysis of Randomized Controlled Trials (RCTs) to support clinical and evidence-based research. Our services focus on evaluating trial design, statistical methodologies, bias assessment, and meta-analysis to ensure the highest standards of research integrity and scientific rigor.

Our Services

1. Critical Appraisal of RCT Design and Methodology

We conduct an in-depth evaluation of RCT methodologies to assess their validity and reliability, including:

Randomization Techniques – Assessment of simple, stratified, block, and cluster randomization methods.
Blinding Strategies – Evaluating single, double, and triple blinding approaches for reducing bias.
Control Group Selection – Comparison of active control, placebo, and standard-of-care groups.
Sample Size Calculation – Ensuring adequate power and statistical significance.
Endpoints and Outcome Measures – Reviewing primary, secondary, and surrogate endpoints.

2. Statistical Analysis and Interpretation

Our expertise in biostatistics enables us to perform robust statistical analyses, including:

Intention-to-Treat (ITT) vs. Per-Protocol (PP) Analysis – Evaluating the impact of adherence on trial outcomes.
Descriptive and Inferential Statistics – Calculation of means, medians, confidence intervals, and p-values.
Survival Analysis – Using Kaplan-Meier curves and Cox proportional hazards models.
Multivariate Regression Models – Adjusting for confounding variables in RCTs.
Subgroup Analysis and Interaction Testing – Identifying differential treatment effects.

3. Bias Assessment and Quality Evaluation

We systematically assess potential biases that may compromise trial validity using:

Cochrane Risk of Bias Tool (RoB 2) – Evaluating selection, performance, detection, attrition, and reporting bias.
GRADE Approach (Grading of Recommendations, Assessment, Development, and Evaluations) – Assessing certainty of evidence.
Heterogeneity Analysis – Measuring statistical inconsistency using I² statistics.
Publication Bias Detection – Using funnel plots and Egger’s regression test.

4. Meta-Analysis and Systematic Review Support

We provide advanced meta-analysis solutions to synthesize RCT findings, including:

Fixed-Effect vs. Random-Effects Models – Choosing the optimal model based on study heterogeneity.
Forest Plot and Funnel Plot Generation – Visualizing treatment effects and bias.
Network Meta-Analysis – Comparing multiple interventions in a single framework.
Bayesian Meta-Analysis – Incorporating prior probabilities for robust conclusions.
Sensitivity and Subgroup Analyses – Exploring robustness and sources of heterogeneity.

5. Regulatory Compliance and Ethical Considerations

We ensure adherence to international guidelines and ethical research principles, including:

CONSORT Guidelines (Consolidated Standards of Reporting Trials) – Evaluating trial reporting quality.
ICH-GCP (International Conference on Harmonization - Good Clinical Practice) – Ensuring ethical trial conduct.
FDA, EMA, and WHO Compliance – Aligning analyses with global regulatory standards.
Ethical Considerations in RCTs – Evaluating informed consent processes and data transparency.

Industries We Serve

Our RCT analysis services cater to a diverse range of sectors, including:

Pharmaceutical and Biotech Companies – Supporting drug efficacy and safety assessments.
Clinical Research Organizations (CROs) – Providing statistical and methodological expertise.
Academic and Research Institutions – Assisting in high-impact publication and grant applications.
Public Health Organizations – Informing policy decisions through evidence synthesis.

Why Choose Clievi.com?

Expert Team of Biostatisticians, Epidemiologists, and Medical Researchers – Ensuring methodological excellence.
Advanced Statistical and Machine Learning Tools – Providing data-driven insights.
Regulatory-Compliant and Ethical Research Practices – Aligning with global standards.
Customizable and Scalable Solutions – Tailored to meet research and clinical needs.

Contact Us

Enhance the credibility and impact of your Randomized Controlled Trials (RCTs) with our expert analysis services. Contact Clievi.com today to explore how we can support your clinical research and evidence-based decision-making.