Systematic Literature Review (SLR) Services
Comprehensive Evidence Synthesis for Real-World Evidence & Health Economics Outcomes Research
A Systematic Literature Review (SLR) is a rigorous, methodologically structured process that identifies, evaluates, and synthesizes all relevant published and unpublished evidence on a specific research question. In Real-World Evidence (RWE) and Health Economics and Outcomes Research (HEOR), SLRs play a critical role in informing regulatory decisions, payer submissions, health technology assessments (HTAs), and clinical guidelines.
At Clievi, we provide high-quality, reproducible, and methodologically sound systematic literature reviews, tailored to pharmaceutical, biotechnology, medical device, and healthcare industry stakeholders. Our expertise spans across clinical effectiveness, economic evaluations, burden of disease assessments, epidemiological studies, and patient-reported outcomes (PROs).
Our Systematic Literature Review (SLR) Services
1. Research Question Development & Protocol Design
A well-defined research question is essential for an effective SLR. Our process includes:
- PICO Framework Development – Formulating research questions based on Population, Intervention, Comparator, and Outcomes (PICO) criteria.
- Eligibility Criteria Definition – Establishing inclusion and exclusion criteria aligned with PRISMA, Cochrane, and Centre for Reviews and Dissemination (CRD) guidelines.
- Protocol Development – Creating a predefined research strategy following PROSPERO registration requirements.
2. Comprehensive Literature Search & Data Extraction
We conduct exhaustive, structured searches across multiple biomedical, economic, and regulatory databases to ensure comprehensive evidence retrieval.
Data Sources We Search
- Clinical & Biomedical Literature – PubMed, Embase, Cochrane Library, Web of Science, Scopus
- Health Economics & Outcomes Research (HEOR) Databases – Tufts CEA Registry, ISPOR, AMCP dossiers
- Regulatory & HTA Reports – NICE, ICER, CADTH, PBAC, G-BA, HAS, FDA, EMA
- Real-World Data (RWD) & Epidemiology Sources – EHRs, claims databases, patient registries
- Clinical Trial Registries – ClinicalTrials.gov, EU Clinical Trials Register, WHO ICTRP
Data Extraction & Management
- Structured Data Collection Forms – Using Cochrane Collaboration’s data extraction templates
- Double Data Extraction & Quality Control – Ensuring accuracy and reproducibility
- Data Categorization – Stratifying studies based on study design, outcomes, patient population, intervention types
3. Critical Appraisal & Quality Assessment
To ensure methodological rigor, we perform critical appraisal and bias assessment using:
- Cochrane Risk of Bias Tool (RoB 2.0) – For randomized controlled trials (RCTs)
- Newcastle-Ottawa Scale (NOS) – For observational studies (cohort, case-control)
- GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) – Evaluating overall evidence strength
- CHEERS Guidelines – For economic evaluations
Our quality appraisal process ensures that all included studies meet regulatory and payer expectations for reliability and validity.
4. Data Synthesis & Evidence Interpretation
We apply quantitative and qualitative synthesis techniques to generate clinically and economically relevant insights.
Types of Evidence Synthesis
- Narrative Synthesis – Structured qualitative summaries of study results, trends, and gaps
- Meta-analysis – Combining data from multiple studies for pooled effect estimates
- Network Meta-analysis (NMA) – Evaluating multiple treatment comparisons using Bayesian or Frequentist approaches
- Comparative Effectiveness Analysis – Analyzing treatment efficacy and safety outcomes
5. Systematic Review for HTA & Market Access Submissions
We tailor our SLR outputs to meet HTA and reimbursement submission requirements for key global agencies:
- NICE (UK) – Comparative effectiveness and cost-effectiveness analyses
- CADTH (Canada) – HEOR-based assessments for pharmaceutical reimbursement
- ICER (US) – Cost-effectiveness and economic modeling requirements
- G-BA & IQWiG (Germany) – Health economic evaluations for pricing negotiations
- PBAC (Australia) – Pharmaceutical Benefits Advisory Committee dossiers
Our HTA-aligned systematic reviews enhance market access strategies by providing robust evidence to support payer negotiations.
Applications of Systematic Literature Reviews in RWE & HEOR
- Health Technology Assessments (HTA) – Evidence synthesis for drug and device approvals
- Economic Evaluations – Supporting cost-effectiveness, budget impact, and pricing analyses
- Burden of Disease & Epidemiology Studies – Assessing disease prevalence, healthcare utilization, and unmet needs
- Comparative Effectiveness Research (CER) – Evaluating treatment efficacy and safety across multiple interventions
- Real-World Evidence (RWE) Integration – Identifying real-world treatment patterns and outcomes
Why Choose Clievi for Systematic Literature Review (SLR) Services?
- Expert-Led Evidence Synthesis – Conducted by epidemiologists, biostatisticians, and HEOR specialists
- Regulatory & HTA Compliance – Adhering to PRISMA, Cochrane, GRADE, AMSTAR, and NICE guidelines
- Advanced Data Extraction & Synthesis Tools – Using DistillerSR, Covidence, RevMan, and R for systematic review automation
- Customization for Global Market Access – Providing tailored SLR reports for HTA submissions and payer evidence dossiers
- End-to-End Literature Review Management – From protocol development to manuscript writing and publication support
Deliverables of Our SLR Services
- Systematic Literature Review Report – PRISMA-compliant, structured synthesis of clinical and economic evidence
- Meta-analysis and Network Meta-analysis Reports – Pooled treatment effect estimates and indirect comparisons
- Evidence Gap Analysis – Identifying limitations and research opportunities
- HTA & Market Access-Ready Dossier – Supporting regulatory submissions and payer engagements
- Manuscript Development & Scientific Publications – Preparing high-impact articles for peer-reviewed journals
Get in Touch
Ensure regulatory-compliant, high-impact systematic reviews with Clievi’s data-driven, methodologically sound, and HTA-aligned SLR services.
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Website: www.clievi.com